Db file sequential reads are indexed reads of a single block. If the application consistently has waits this long, the performance will be noticeably slow. If you're experiencing waits on this event you should identify which tablespaces or objects these are occurring on.
Considerations:
Review the raid configuration
and disk speed for the affected
tablespaces. Make sure that they are
spread properly across high speed
disks. Consideration should be given
to isolating these tablespaces on
their own disk. Consider running AWR
reports for various times of day
over the course of several weeks to
see if there is a pattern of which
objects have high buffer busy waits.
If there is, consider setting the
INITRANS higher on those objects. If
your instance is Oracle applications
database, changing the INITRANS
setting will need to be reviewed by
Oracle.